|
KMID : 0606320060230010001
|
|
Journal of Phamacetical Sciences Sookmyung Women s University
2006 Volume.23 No. 1 p.1 ~ p.5
|
|
|
Cytotoxicity of chitosan on cancer cell lines
|
|
Min Soon-Hong
Pyo Myoung-Yun
|
|
|
Abstract
|
|
|
|
We investigated the cytotoxicity of chitosan on cancer cell lines (P388, L1210, HCT-15, and SK-HepG-1) and mouse splenocytes as normal cells by MTT assay. Chitosan (37.5μg/ml, 75μg/ml, 112.5μg/ml, and 150μg/ml) showed dose-dependent cytotoxicity against the cancer cell lines. Particularly, chitosan showed lower cytotoxicity against the normal mouse splenocytes than against the cancer cell lines at high doses (112.5μg/ml and 150μg/ml). These results indicate that chitosan may selectively induce growth inhibition in cancer cell lines.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|